In several myeloid and lymphoid malignancies, driver mutations resulting in constitutive JAK activation can be found. The paradigm is represented by BCR-ABL1 one. Cytokine binding induces or re-orients receptor dimerization, such that JAK kinase domains experience each other in a effective conformation for transactivation and phosphorylation with the cytokine receptor https://hatshepsutq630hmr4.law-wiki.com/user