Hofmann’s Focus on ergot led him down a route of isolating and synthesizing its compounds. The main focus was on creating a respiratory and circulatory stimulant. It can be thought that LSD and other psychedelics might interact with the DMN in making the consequences that manifest when to the material. https://medium.com/@LsdWorld/the-future-of-lsd-research-and-potential-medical-uses-40ebd16dd150